Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3908292..3908889 Replicon chromosome
Accession NZ_CP118405
Organism Klebsiella pneumoniae strain F3-2P(2*)

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag HX883_RS19080 Protein ID WP_004142563.1
Coordinates 3908572..3908889 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HX883_RS19075 Protein ID WP_004142561.1
Coordinates 3908292..3908579 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX883_RS19045 (3904373) 3904373..3904621 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HX883_RS19050 (3904639) 3904639..3904980 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HX883_RS19055 (3905011) 3905011..3906126 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
HX883_RS19060 (3906305) 3906305..3906886 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
HX883_RS19065 (3906886) 3906886..3907254 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HX883_RS19070 (3907374) 3907374..3908027 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HX883_RS19075 (3908292) 3908292..3908579 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HX883_RS19080 (3908572) 3908572..3908889 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HX883_RS19085 (3909074) 3909074..3910117 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
HX883_RS19090 (3910784) 3910784..3911650 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
HX883_RS19095 (3911759) 3911759..3913186 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T273119 WP_004142563.1 NZ_CP118405:c3908889-3908572 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT273119 WP_004142561.1 NZ_CP118405:c3908579-3908292 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References