Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3828890..3829487 Replicon chromosome
Accession NZ_CP118398
Organism Klebsiella pneumoniae strain 2020CK-00223

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag PWK27_RS19045 Protein ID WP_004893639.1
Coordinates 3829170..3829487 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag PWK27_RS19040 Protein ID WP_004142561.1
Coordinates 3828890..3829177 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWK27_RS19010 (PWK27_19010) 3824970..3825218 + 249 WP_232553871.1 DUF1158 domain-containing protein -
PWK27_RS19015 (PWK27_19015) 3825236..3825577 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
PWK27_RS19020 (PWK27_19020) 3825608..3826723 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
PWK27_RS19025 (PWK27_19025) 3826903..3827487 + 585 WP_274759214.1 TetR/AcrR family transcriptional regulator -
PWK27_RS19030 (PWK27_19030) 3827484..3827852 + 369 WP_002893024.1 MmcQ/YjbR family DNA-binding protein -
PWK27_RS19035 (PWK27_19035) 3827972..3828625 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
PWK27_RS19040 (PWK27_19040) 3828890..3829177 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
PWK27_RS19045 (PWK27_19045) 3829170..3829487 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWK27_RS19050 (PWK27_19050) 3829672..3830715 - 1044 WP_021314069.1 DUF2157 domain-containing protein -
PWK27_RS19055 (PWK27_19055) 3831381..3832247 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
PWK27_RS19060 (PWK27_19060) 3832356..3833783 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T273100 WP_004893639.1 NZ_CP118398:c3829487-3829170 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT273100 WP_004142561.1 NZ_CP118398:c3829177-3828890 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References