Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4776211..4776469 Replicon chromosome
Accession NC_017632
Organism Escherichia coli UM146

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag UM146_RS23690 Protein ID WP_000809168.1
Coordinates 4776211..4776363 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4776412..4776469 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UM146_RS23670 4771456..4772169 - 714 WP_001102393.1 acidic protein MsyB -
UM146_RS23675 4772195..4772599 - 405 WP_000843687.1 DUF2541 family protein -
UM146_RS23680 4772971..4774887 + 1917 WP_000516135.1 molecular chaperone DnaK -
UM146_RS23685 4774976..4776106 + 1131 WP_001118464.1 molecular chaperone DnaJ -
UM146_RS23690 4776211..4776363 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4776412..4776469 + 58 - - Antitoxin
UM146_RS23695 4776974..4777735 + 762 WP_001274823.1 hypothetical protein -
UM146_RS23700 4777755..4779248 + 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
UM146_RS23705 4779377..4780636 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T27301 WP_000809168.1 NC_017632:c4776363-4776211 [Escherichia coli UM146]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T27301 NC_017632:c4776363-4776211 [Escherichia coli UM146]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT27301 NC_017632:4776412-4776469 [Escherichia coli UM146]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References