Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5769842..5770542 Replicon chromosome
Accession NZ_CP118233
Organism Micromonospora chalcea strain 1K05785M01

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PVK74_RS26120 Protein ID WP_274477441.1
Coordinates 5769842..5770234 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PVK74_RS26125 Protein ID WP_013284175.1
Coordinates 5770231..5770542 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK74_RS26100 (PVK74_26100) 5765347..5766171 + 825 WP_043326456.1 ABC transporter permease -
PVK74_RS26105 (PVK74_26105) 5766168..5767589 + 1422 WP_043326455.1 FAD-dependent oxidoreductase -
PVK74_RS26110 (PVK74_26110) 5767589..5768791 + 1203 WP_274477439.1 saccharopine dehydrogenase C-terminal domain-containing protein -
PVK74_RS26115 (PVK74_26115) 5768788..5769801 + 1014 WP_274477440.1 agmatinase -
PVK74_RS26120 (PVK74_26120) 5769842..5770234 + 393 WP_274477441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVK74_RS26125 (PVK74_26125) 5770231..5770542 + 312 WP_013284175.1 XRE family transcriptional regulator Antitoxin
PVK74_RS26130 (PVK74_26130) 5770562..5771005 - 444 WP_274477442.1 hypothetical protein -
PVK74_RS26135 (PVK74_26135) 5771103..5771450 - 348 WP_043326443.1 DUF779 domain-containing protein -
PVK74_RS26140 (PVK74_26140) 5771450..5772955 - 1506 WP_043326441.1 aldehyde dehydrogenase family protein -
PVK74_RS26145 (PVK74_26145) 5772996..5774279 - 1284 WP_064447716.1 hypothetical protein -
PVK74_RS26150 (PVK74_26150) 5774515..5775180 + 666 WP_043326436.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-117)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-91)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14833.80 Da        Isoelectric Point: 10.2632

>T272966 WP_274477441.1 NZ_CP118233:5769842-5770234 [Micromonospora chalcea]
MGADGKRWSVRVTGEVRHWLRDLRDHDPASYESVRVAVDKLAEVGPGLGRPLVDTLRGSSLRNLKELRPRSGRDVAIWVL
FVFDPWSQAVLLVAGNKAGDWSRWYRQHIPAAEVAYKAWLDSERERRGES

Download         Length: 393 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11668.90 Da        Isoelectric Point: 4.3953

>AT272966 WP_013284175.1 NZ_CP118233:5770231-5770542 [Micromonospora chalcea]
VTEFYHWDEVRAELGGDDEAYEAERARTDAWVSAFHLAEERKRLGLTQRQVAEIMGVTPGRVSQIENGDLDVNEVATLSR
YANALGARLRIIFDYGDDLRQIA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References