Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5115659..5116329 Replicon chromosome
Accession NZ_CP118233
Organism Micromonospora chalcea strain 1K05785M01

Toxin (Protein)


Gene name HigB2 Uniprot ID A0A505H956
Locus tag PVK74_RS22940 Protein ID WP_043330725.1
Coordinates 5115659..5116012 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W7VGY7
Locus tag PVK74_RS22945 Protein ID WP_043327344.1
Coordinates 5116009..5116329 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK74_RS22915 (PVK74_22915) 5111080..5111400 + 321 WP_043327353.1 type VII secretion target -
PVK74_RS22920 (PVK74_22920) 5111410..5112336 + 927 WP_043327351.1 WXG100 family type VII secretion target -
PVK74_RS22925 (PVK74_22925) 5112346..5112699 + 354 WP_043327350.1 YbaB/EbfC family nucleoid-associated protein -
PVK74_RS22930 (PVK74_22930) 5112704..5113303 + 600 WP_274477179.1 hypothetical protein -
PVK74_RS22935 (PVK74_22935) 5113359..5115422 - 2064 WP_043327346.1 AAA family ATPase -
PVK74_RS22940 (PVK74_22940) 5115659..5116012 + 354 WP_043330725.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVK74_RS22945 (PVK74_22945) 5116009..5116329 + 321 WP_043327344.1 helix-turn-helix transcriptional regulator Antitoxin
PVK74_RS22950 (PVK74_22950) 5116385..5116966 + 582 WP_043327342.1 winged helix-turn-helix domain-containing protein -
PVK74_RS22955 (PVK74_22955) 5117007..5118248 + 1242 WP_274477180.1 MFS transporter -
PVK74_RS22960 (PVK74_22960) 5118386..5119237 + 852 WP_209959669.1 menaquinone biosynthesis protein -
PVK74_RS22965 (PVK74_22965) 5119282..5120217 - 936 WP_274477181.1 hypothetical protein -
PVK74_RS22970 (PVK74_22970) 5120217..5121197 - 981 WP_274477182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-92)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13557.31 Da        Isoelectric Point: 4.7878

>T272965 WP_043330725.1 NZ_CP118233:5115659-5116012 [Micromonospora chalcea]
MTGQVEDFLDELYAADRESHRLVNQAILVLERNGPIEGRPLVDSITASRLSNLKELRPPSAGRTEIRILFVFDPWRSAVL
LVAGDKSGQWTRWYRDAIPEAEQLYDTYLKERQEEIR

Download         Length: 354 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11456.15 Da        Isoelectric Point: 9.9878

>AT272965 WP_043327344.1 NZ_CP118233:5116009-5116329 [Micromonospora chalcea]
MSGVKRWRDTSHLGRAVETAGGVQAFEAAIGGMLDEARGWRLAELRKRREMTQEQVALRMGVSVARVSQIEAGSVATQDV
LARYIAALGGTLKLIADFGDEQLKVA

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A505H956

Antitoxin

Source ID Structure
AlphaFold DB A0A505HF97

References