Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1951100..1951760 Replicon chromosome
Accession NZ_CP118223
Organism Klebsiella grimontii strain YWC001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PVK07_RS09220 Protein ID WP_049089248.1
Coordinates 1951100..1951453 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag PVK07_RS09225 Protein ID WP_004132739.1
Coordinates 1951458..1951760 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK07_RS09195 (PVK07_09195) 1946484..1947251 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
PVK07_RS09200 (PVK07_09200) 1947241..1947849 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
PVK07_RS09205 (PVK07_09205) 1947864..1948490 - 627 WP_004132731.1 hypothetical protein -
PVK07_RS09210 (PVK07_09210) 1948630..1949298 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
PVK07_RS09215 (PVK07_09215) 1949298..1950716 + 1419 WP_224250950.1 heavy metal sensor histidine kinase -
PVK07_RS09220 (PVK07_09220) 1951100..1951453 + 354 WP_049089248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVK07_RS09225 (PVK07_09225) 1951458..1951760 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
PVK07_RS09230 (PVK07_09230) 1951954..1952157 + 204 Protein_1808 hypothetical protein -
PVK07_RS09235 (PVK07_09235) 1952158..1952491 + 334 Protein_1809 type II toxin-antitoxin system PemK/MazF family toxin -
PVK07_RS09245 (PVK07_09245) 1952815..1954272 + 1458 WP_224250915.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
PVK07_RS09255 (PVK07_09255) 1955301..1956755 - 1455 WP_024359975.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13639.64 Da        Isoelectric Point: 9.8874

>T272947 WP_049089248.1 NZ_CP118223:1951100-1951453 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT272947 WP_004132739.1 NZ_CP118223:1951458-1951760 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References