Detailed information of TA system TA272936

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrE/-
• Location: 2234716..2234979
• Replicon: chromosome
• Accession: NZ_CP118167
• Organism: Bacillus subtilis strain 21855

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: PUW21_RS11485
• Protein ID: WP_009967548.1
• Coordinates: 2234716..2234832 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrE
Locus tag	-
Coordinates	2234824..2234979 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW21_RS11445	2229806..2230057	+	252	WP_061891069.1	phage holin	-
PUW21_RS11450	2230185..2231321	+	1137	WP_019712879.1	tetratricopeptide repeat protein	-
PUW21_RS11455	2231311..2231487	+	177	WP_061891068.1	hypothetical protein	-
PUW21_RS11460	2231529..2232779	-	1251	WP_274357910.1	UV damage repair protein UvrX	-
PUW21_RS11465	2232772..2233104	-	333	WP_061891067.1	YolD-like family protein	-
PUW21_RS11470	2233277..2233612	+	336	WP_041336417.1	hypothetical protein	-
PUW21_RS11475	2233655..2234011	-	357	WP_072566416.1	hypothetical protein	-
PUW21_RS11480	2234017..2234484	-	468	WP_041336414.1	YolA family protein	-
PUW21_RS11485	2234716..2234832	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2234824..2234979	-	156	-	-	Antitoxin
PUW21_RS11490	2235149..2235646	-	498	WP_003246188.1	SMI1/KNR4 family protein	-
PUW21_RS11495	2235655..2237370	-	1716	WP_274357911.1	ribonuclease YeeF family protein	-
PUW21_RS11500	2237622..2238623	+	1002	WP_250620705.1	hypothetical protein	-
PUW21_RS11505	2238657..2239193	-	537	WP_213377332.1	SMI1/KNR4 family protein	-
PUW21_RS11510	2239280..2239531	-	252	WP_213377330.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2120487..2245041	124554
	-	inside	Prophage	-	-	2120487..2243085	122598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T272936 WP_009967548.1 NZ_CP118167:2234716-2234832 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

Antitoxin

Nucleotide

• Length: 156 bp

>AT272936 NZ_CP118167:c2234979-2234824 [Bacillus subtilis]
ATTTCTTTAATGAGAAATGCATAAAATAAAAAGACCAGGGTGTTGGCGCACCCCGGCTCTGTACAAAAAGCTGCCCGTCA
AAGGGCTTACTCGATGTTCAATCTGCGTAGACCTAACCCTTTAAGGTTCCTAAGCTCAAGGGAAGGTCTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin