Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1161518..1162168 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name higB Uniprot ID A0A1S9ZYD2
Locus tag PUV55_RS05640 Protein ID WP_021115585.1
Coordinates 1161518..1161856 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUV55_RS05645 Protein ID WP_005710405.1
Coordinates 1161860..1162168 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS05595 (PUV55_05595) 1157088..1157462 + 375 WP_010786049.1 cytochrome b562 -
PUV55_RS05600 (PUV55_05600) 1157602..1158536 + 935 Protein_1105 IS256 family transposase -
PUV55_RS05605 (PUV55_05605) 1158491..1158757 + 267 Protein_1106 cation-transporting ATPase PacS -
PUV55_RS05615 (PUV55_05615) 1159240..1160679 - 1440 WP_005710409.1 glutamate--tRNA ligase -
PUV55_RS05640 (PUV55_05640) 1161518..1161856 + 339 WP_021115585.1 selenocysteine synthase Toxin
PUV55_RS05645 (PUV55_05645) 1161860..1162168 + 309 WP_005710405.1 helix-turn-helix domain-containing protein Antitoxin
PUV55_RS05650 (PUV55_05650) 1162369..1163529 + 1161 WP_005710403.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
PUV55_RS05655 (PUV55_05655) 1163629..1164210 + 582 WP_021110392.1 type IV pilus biogenesis/stability protein PilW -
PUV55_RS05660 (PUV55_05660) 1164271..1165206 + 936 WP_005710401.1 KpsF/GutQ family sugar-phosphate isomerase -
PUV55_RS05665 (PUV55_05665) 1165206..1165694 + 489 WP_005710400.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1157602..1158141 539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-86)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13258.29 Da        Isoelectric Point: 10.0084

>T272920 WP_021115585.1 NZ_CP118165:1161518-1161856 [Glaesserella parasuis]
MNVAFVELPPFEEYRKKYLDDDSFRLLQNELLKFPDKGELIQGTGGLRKLRIVDIIRQKGKRGGARVIYYYYVRGKQVWL
FHAYNKNQQDDLSNEERVVLANTLSYLKSLVR

Download         Length: 339 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11539.61 Da        Isoelectric Point: 10.2919

>AT272920 WP_005710405.1 NZ_CP118165:1161860-1162168 [Glaesserella parasuis]
MGKLFNELMEGMQALELHLQGKITLKTTVVEVPDPIVITPEEVKAIRQKLNLSQAVFARKLHTSVRTYQGWEQGRTKPNP
QAVLLLKMVEKSPKTFEQIASI

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S9ZYD2

Antitoxin

Source ID Structure

References