Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 587906..588467 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name higB Uniprot ID A0A143CE91
Locus tag PUV55_RS03000 Protein ID WP_005712614.1
Coordinates 587906..588184 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PUV55_RS03005 Protein ID WP_005712616.1
Coordinates 588195..588467 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS02985 (PUV55_02985) 583698..585026 - 1329 WP_010786775.1 exodeoxyribonuclease VII large subunit -
PUV55_RS02990 (PUV55_02990) 585140..586402 - 1263 WP_012621704.1 serine hydroxymethyltransferase -
PUV55_RS02995 (PUV55_02995) 586749..587759 - 1011 WP_274360165.1 ornithine carbamoyltransferase -
PUV55_RS03000 (PUV55_03000) 587906..588184 + 279 WP_005712614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUV55_RS03005 (PUV55_03005) 588195..588467 + 273 WP_005712616.1 HigA family addiction module antitoxin Antitoxin
PUV55_RS03010 (PUV55_03010) 588531..589751 + 1221 WP_005712618.1 ATP-dependent RNA helicase RhlB -
PUV55_RS03015 (PUV55_03015) 589818..590069 + 252 Protein_590 DUF853 family protein -
PUV55_RS03020 (PUV55_03020) 590141..591355 - 1215 WP_021114868.1 ATP-binding protein -
PUV55_RS03025 (PUV55_03025) 591562..592101 - 540 WP_005714441.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10326.71 Da        Isoelectric Point: 10.0505

>T272918 WP_005712614.1 NZ_CP118165:587906-588184 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKFQN
GHAEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT272918 WP_005712616.1 NZ_CP118165:588195-588467 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CE91

Antitoxin

Source ID Structure

References