Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 389438..390081 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUV55_RS01965 Protein ID WP_021113598.1
Coordinates 389438..389782 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUV55_RS01970 Protein ID WP_160440844.1
Coordinates 389785..390081 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS01950 (PUV55_01950) 385152..385556 - 405 WP_274359965.1 hypothetical protein -
PUV55_RS01955 (PUV55_01955) 386043..387134 - 1092 WP_005714201.1 murein transglycosylase A -
PUV55_RS01960 (PUV55_01960) 387245..389224 - 1980 WP_160429074.1 exoribonuclease II -
PUV55_RS01965 (PUV55_01965) 389438..389782 + 345 WP_021113598.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUV55_RS01970 (PUV55_01970) 389785..390081 + 297 WP_160440844.1 NadS family protein Antitoxin
PUV55_RS01975 (PUV55_01975) 390138..391100 + 963 WP_026917107.1 WYL domain-containing protein -
PUV55_RS01980 (PUV55_01980) 391176..391949 + 774 WP_035519505.1 PD-(D/E)XK nuclease family protein -
PUV55_RS01985 (PUV55_01985) 391966..392613 + 648 WP_016527812.1 hypothetical protein -
PUV55_RS01990 (PUV55_01990) 392892..393608 + 717 WP_016527813.1 cell division protein FtsZ -
PUV55_RS01995 (PUV55_01995) 393653..394622 + 970 Protein_390 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(51-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13277.25 Da        Isoelectric Point: 5.9233

>T272917 WP_021113598.1 NZ_CP118165:389438-389782 [Glaesserella parasuis]
METEEYLTFIETKIFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11181.14 Da        Isoelectric Point: 8.8246

>AT272917 WP_160440844.1 NZ_CP118165:389785-390081 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTLHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPELIPVLQGL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References