Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2698076..2698662 Replicon chromosome
Accession NZ_CP118153
Organism Pseudomonas chlororaphis strain ATCC 17811

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag PUP50_RS12500 Protein ID WP_274306201.1
Coordinates 2698384..2698662 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PUP50_RS12495 Protein ID WP_274306200.1
Coordinates 2698076..2698375 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP50_RS12470 (PUP50_12470) 2695479..2695817 + 339 WP_274306195.1 phage tail protein -
PUP50_RS12475 (PUP50_12475) 2695827..2696576 + 750 WP_274306196.1 phage minor tail protein L -
PUP50_RS12480 (PUP50_12480) 2696579..2697343 + 765 WP_274306197.1 C40 family peptidase -
PUP50_RS12485 (PUP50_12485) 2697369..2697533 + 165 WP_274306198.1 hypothetical protein -
PUP50_RS12490 (PUP50_12490) 2697526..2697765 - 240 WP_274306199.1 hypothetical protein -
PUP50_RS12495 (PUP50_12495) 2698076..2698375 - 300 WP_274306200.1 HigA family addiction module antitoxin Antitoxin
PUP50_RS12500 (PUP50_12500) 2698384..2698662 - 279 WP_274306201.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP50_RS12505 (PUP50_12505) 2698807..2699229 + 423 WP_274306202.1 hypothetical protein -
PUP50_RS12510 (PUP50_12510) 2699272..2699880 + 609 WP_274306203.1 tail assembly protein -
PUP50_RS12515 (PUP50_12515) 2699916..2700179 + 264 WP_274306204.1 hypothetical protein -
PUP50_RS12520 (PUP50_12520) 2700163..2700393 - 231 WP_274306205.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2653426..2762588 109162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10555.89 Da        Isoelectric Point: 6.7108

>T272887 WP_274306201.1 NZ_CP118153:c2698662-2698384 [Pseudomonas chlororaphis]
MIRSFACADTEALFTTGRTRRWADIKSVAERKLAALDAAKELRDLRSPPGNRLHSLEGDREGQHSISINMQWRVCFIWTE
NGPENVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10836.40 Da        Isoelectric Point: 5.0994

>AT272887 WP_274306200.1 NZ_CP118153:c2698375-2698076 [Pseudomonas chlororaphis]
MFKNGMRPVHPGEVLREDFQSEMGFSAAALARALGVSTPTVNNILLERGGVSADMALRLAACLDTTPEFWLNLQTAYELR
KAEQEHGEEIAVAVHRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References