Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1753085..1753779 Replicon chromosome
Accession NZ_CP118135
Organism Pseudomonas chlororaphis strain NCCB 820532

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUP76_RS08045 Protein ID WP_274301666.1
Coordinates 1753483..1753779 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUP76_RS08040 Protein ID WP_009041852.1
Coordinates 1753085..1753486 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP76_RS08030 (PUP76_08030) 1748219..1751569 + 3351 WP_123573332.1 mechanosensitive channel MscK -
PUP76_RS08035 (PUP76_08035) 1751618..1753081 + 1464 WP_123412254.1 YdiU family protein -
PUP76_RS08040 (PUP76_08040) 1753085..1753486 - 402 WP_009041852.1 transcriptional regulator Antitoxin
PUP76_RS08045 (PUP76_08045) 1753483..1753779 - 297 WP_274301666.1 type II toxin-antitoxin system HigB family toxin Toxin
PUP76_RS08050 (PUP76_08050) 1754017..1754451 + 435 WP_062823885.1 thioredoxin TrxC -
PUP76_RS08055 (PUP76_08055) 1754490..1755260 - 771 WP_009041850.1 ParA family protein -
PUP76_RS08060 (PUP76_08060) 1755595..1756326 + 732 WP_274301667.1 beta-ketoacyl synthase chain length factor -
PUP76_RS08065 (PUP76_08065) 1756302..1757117 + 816 WP_009041848.1 lysophospholipid acyltransferase family protein -
PUP76_RS08070 (PUP76_08070) 1757092..1757352 + 261 WP_007926834.1 phosphopantetheine-binding protein -
PUP76_RS08075 (PUP76_08075) 1757362..1757616 + 255 WP_007926835.1 acyl carrier protein -
PUP76_RS08080 (PUP76_08080) 1757613..1758158 + 546 WP_062823888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11587.38 Da        Isoelectric Point: 10.6515

>T272766 WP_274301666.1 NZ_CP118135:c1753779-1753483 [Pseudomonas chlororaphis]
MHIITAKRIWEAKNRWPQSANALETWYRKAKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14854.92 Da        Isoelectric Point: 4.5430

>AT272766 WP_009041852.1 NZ_CP118135:c1753486-1753085 [Pseudomonas chlororaphis]
MNVLVKQAADHWHFVAPVLRKPKTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References