272760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1826317..1826921 Replicon chromosome
Accession NZ_CP118134
Organism Pseudomonas synxantha strain ATCC 17413

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUP72_RS08225 Protein ID WP_046071432.1
Coordinates 1826607..1826921 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUP72_RS08220 Protein ID WP_003189536.1
Coordinates 1826317..1826604 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP72_RS08185 (PUP72_08185) 1822079..1822792 + 714 WP_010212191.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PUP72_RS08195 (PUP72_08195) 1823087..1823482 + 396 WP_046071429.1 nucleotidyltransferase domain-containing protein -
PUP72_RS08200 (PUP72_08200) 1823472..1823891 + 420 WP_274358134.1 DUF86 domain-containing protein -
PUP72_RS08205 (PUP72_08205) 1823924..1824004 - 81 Protein_1614 type II toxin-antitoxin system RelB/DinJ family antitoxin -
PUP72_RS08210 (PUP72_08210) 1824527..1824778 + 252 WP_005786036.1 hypothetical protein -
PUP72_RS08215 (PUP72_08215) 1824852..1826078 - 1227 WP_059397051.1 MFS transporter -
PUP72_RS08220 (PUP72_08220) 1826317..1826604 - 288 WP_003189536.1 NadS family protein Antitoxin
PUP72_RS08225 (PUP72_08225) 1826607..1826921 - 315 WP_046071432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP72_RS08230 (PUP72_08230) 1827027..1827968 - 942 WP_274358135.1 LysR family transcriptional regulator -
PUP72_RS08235 (PUP72_08235) 1828126..1829442 + 1317 WP_068966592.1 MFS transporter -
PUP72_RS08240 (PUP72_08240) 1829454..1830683 + 1230 WP_056847345.1 Zn-dependent hydrolase -
PUP72_RS08245 (PUP72_08245) 1830695..1831732 + 1038 WP_046071436.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1824527..1837804 13277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11670.57 Da        Isoelectric Point: 10.0575

>T272760 WP_046071432.1 NZ_CP118134:c1826921-1826607 [Pseudomonas synxantha]
MIFIETSVFTRRVKELIDEDAYMALQNVLVVNPSAGDVIEGTGGVRKIRVAAKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTAVERKSLKAAIEHWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10828.41 Da        Isoelectric Point: 7.3219

>AT272760 WP_003189536.1 NZ_CP118134:c1826604-1826317 [Pseudomonas synxantha]
MSRFFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References