Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1497297..1497945 Replicon chromosome
Accession NZ_CP118078
Organism Streptococcus anginosus strain VSI16

Toxin (Protein)


Gene name higB Uniprot ID F9P6Y3
Locus tag PUW52_RS07420 Protein ID WP_006268450.1
Coordinates 1497580..1497945 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUW52_RS07415 Protein ID WP_150890982.1
Coordinates 1497297..1497590 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW52_RS07395 (PUW52_07395) 1492464..1493510 - 1047 WP_024052823.1 D-alanine--D-alanine ligase -
PUW52_RS07400 (PUW52_07400) 1493643..1494239 - 597 WP_003023742.1 recombination mediator RecR -
PUW52_RS07405 (PUW52_07405) 1494250..1496310 - 2061 WP_180364008.1 penicillin-binding protein PBP2B -
PUW52_RS07410 (PUW52_07410) 1496660..1497205 - 546 WP_150890984.1 hypothetical protein -
PUW52_RS07415 (PUW52_07415) 1497297..1497590 - 294 WP_150890982.1 helix-turn-helix transcriptional regulator Antitoxin
PUW52_RS07420 (PUW52_07420) 1497580..1497945 - 366 WP_006268450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUW52_RS07425 (PUW52_07425) 1498011..1498286 - 276 WP_150890980.1 terminase small subunit -
PUW52_RS07430 (PUW52_07430) 1498366..1498596 - 231 WP_022525741.1 hypothetical protein -
PUW52_RS07435 (PUW52_07435) 1498828..1499238 - 411 WP_150890979.1 hypothetical protein -
PUW52_RS07440 (PUW52_07440) 1499231..1499707 - 477 WP_150890977.1 hypothetical protein -
PUW52_RS07445 (PUW52_07445) 1499754..1500365 - 612 WP_150890975.1 enoyl-CoA hydratase/isomerase family protein -
PUW52_RS07450 (PUW52_07450) 1500454..1500627 - 174 WP_164232034.1 hypothetical protein -
PUW52_RS07455 (PUW52_07455) 1500771..1501616 - 846 WP_150890974.1 ATP-binding protein -
PUW52_RS07460 (PUW52_07460) 1501631..1502437 - 807 WP_150890972.1 phage replisome organizer N-terminal domain-containing protein -
PUW52_RS07465 (PUW52_07465) 1502446..1502712 - 267 WP_150890970.1 HTH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1493643..1510405 16762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14448.63 Da        Isoelectric Point: 9.7920

>T272737 WP_006268450.1 NZ_CP118078:c1497945-1497580 [Streptococcus anginosus]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Download         Length: 366 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10811.48 Da        Isoelectric Point: 4.9123

>AT272737 WP_150890982.1 NZ_CP118078:c1497590-1497297 [Streptococcus anginosus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLDKTLAVVPLEREQV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F9P6Y3

Antitoxin

Source ID Structure

References