Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2798107..2798629 Replicon chromosome
Accession NZ_CP118050
Organism Lacticaseibacillus rhamnosus strain VSI43

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag PUW66_RS13035 Protein ID WP_005687756.1
Coordinates 2798369..2798629 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag PUW66_RS13030 Protein ID WP_005687754.1
Coordinates 2798107..2798376 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW66_RS13010 (PUW66_13010) 2793694..2794263 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
PUW66_RS13015 (PUW66_13015) 2794276..2794785 - 510 WP_005690780.1 transcriptional regulator GutM -
PUW66_RS13020 (PUW66_13020) 2794786..2796654 - 1869 WP_014571687.1 HTH domain-containing protein -
PUW66_RS13025 (PUW66_13025) 2796681..2797481 - 801 WP_005690776.1 SDR family oxidoreductase -
PUW66_RS13030 (PUW66_13030) 2798107..2798376 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PUW66_RS13035 (PUW66_13035) 2798369..2798629 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
PUW66_RS13040 (PUW66_13040) 2798840..2799568 - 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
PUW66_RS13045 (PUW66_13045) 2799765..2800586 + 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
PUW66_RS13050 (PUW66_13050) 2800653..2801540 - 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
PUW66_RS13055 (PUW66_13055) 2801725..2802504 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
PUW66_RS13060 (PUW66_13060) 2802572..2803213 - 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T272728 WP_005687756.1 NZ_CP118050:2798369-2798629 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT272728 WP_005687754.1 NZ_CP118050:2798107-2798376 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References