Detailed information of TA system TA272724

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2520138..2520536
• Replicon: chromosome
• Accession: NZ_CP118048
• Organism: Enterococcus faecalis strain VSI48

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PUW76_RS11985
• Protein ID: WP_023894767.1
• Coordinates: 2520138..2520242 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2520394..2520536 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW76_RS11970 (2515451)	2515451..2516164	-	714	WP_002354877.1	trehalose operon repressor	-
PUW76_RS11975 (2516425)	2516425..2519169	+	2745	WP_129226010.1	glycosyl hydrolase family 65 protein	-
PUW76_RS11980 (2519184)	2519184..2519834	+	651	WP_016614233.1	beta-phosphoglucomutase	-
- (2520018)	2520018..2520205	+	188	NuclAT_4	-	-
PUW76_RS11985 (2520138)	2520138..2520242	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2520394)	2520394..2520536	+	143	NuclAT_10	-	Antitoxin
PUW76_RS11990 (2520627)	2520627..2520749	-	123	WP_002419628.1	hypothetical protein	-
PUW76_RS11995 (2521542)	2521542..2522513	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PUW76_RS12000 (2522688)	2522688..2523125	-	438	WP_010715474.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PUW76_RS12005 (2523258)	2523258..2523812	-	555	WP_033601100.1	nucleoside triphosphate pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T272724 WP_023894767.1 NZ_CP118048:c2520242-2520138 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 143 bp

>AT272724 NZ_CP118048:2520394-2520536 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACCGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Antitoxin