272720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 457691..457945 Replicon chromosome
Accession NZ_CP118048
Organism Enterococcus faecalis strain VSI48

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PUW76_RS02265 Protein ID WP_002355568.1
Coordinates 457691..457807 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 457790..457945 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW76_RS02255 (453129) 453129..455387 + 2259 WP_002363179.1 DNA helicase PcrA -
PUW76_RS02260 (455513) 455513..457543 + 2031 WP_002375948.1 NAD-dependent DNA ligase LigA -
PUW76_RS02265 (457691) 457691..457807 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (457718) 457718..457923 - 206 NuclAT_3 - -
- (457790) 457790..457925 - 136 NuclAT_9 - -
- (457790) 457790..457945 - 156 NuclAT_7 - Antitoxin
PUW76_RS02270 (458125) 458125..458430 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PUW76_RS02275 (458430) 458430..459899 + 1470 WP_002419989.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PUW76_RS02280 (459899) 459899..461329 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PUW76_RS02285 (461348) 461348..462436 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T272720 WP_002355568.1 NZ_CP118048:457691-457807 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 156 bp

>AT272720 NZ_CP118048:c457945-457790 [Enterococcus faecalis]
GAAATATGTTATTATGAAAATGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTG
GTGGCTTACTGAGTTATTGGTTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References