Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1537047..1537695 Replicon chromosome
Accession NZ_CP118046
Organism Streptococcus anginosus strain VSI52

Toxin (Protein)


Gene name higB Uniprot ID F9P6Y3
Locus tag PUW62_RS07680 Protein ID WP_006268450.1
Coordinates 1537330..1537695 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUW62_RS07675 Protein ID WP_150890982.1
Coordinates 1537047..1537340 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW62_RS07655 (PUW62_07655) 1532214..1533260 - 1047 WP_024052823.1 D-alanine--D-alanine ligase -
PUW62_RS07660 (PUW62_07660) 1533393..1533989 - 597 WP_003023742.1 recombination mediator RecR -
PUW62_RS07665 (PUW62_07665) 1534000..1536060 - 2061 WP_180364008.1 penicillin-binding protein PBP2B -
PUW62_RS07670 (PUW62_07670) 1536410..1536955 - 546 WP_150890984.1 hypothetical protein -
PUW62_RS07675 (PUW62_07675) 1537047..1537340 - 294 WP_150890982.1 helix-turn-helix transcriptional regulator Antitoxin
PUW62_RS07680 (PUW62_07680) 1537330..1537695 - 366 WP_006268450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUW62_RS07685 (PUW62_07685) 1537761..1538036 - 276 WP_150890980.1 terminase small subunit -
PUW62_RS07690 (PUW62_07690) 1538116..1538346 - 231 WP_022525741.1 hypothetical protein -
PUW62_RS07695 (PUW62_07695) 1538578..1538988 - 411 WP_150890979.1 hypothetical protein -
PUW62_RS07700 (PUW62_07700) 1538981..1539457 - 477 WP_150890977.1 hypothetical protein -
PUW62_RS07705 (PUW62_07705) 1539504..1540115 - 612 WP_150890975.1 enoyl-CoA hydratase/isomerase family protein -
PUW62_RS07710 (PUW62_07710) 1540204..1540377 - 174 WP_164232034.1 hypothetical protein -
PUW62_RS07715 (PUW62_07715) 1540521..1541366 - 846 WP_150890974.1 ATP-binding protein -
PUW62_RS07720 (PUW62_07720) 1541381..1542187 - 807 WP_150890972.1 phage replisome organizer N-terminal domain-containing protein -
PUW62_RS07725 (PUW62_07725) 1542196..1542462 - 267 WP_150890970.1 HTH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1533393..1550155 16762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14448.63 Da        Isoelectric Point: 9.7920

>T272716 WP_006268450.1 NZ_CP118046:c1537695-1537330 [Streptococcus anginosus]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Download         Length: 366 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10811.48 Da        Isoelectric Point: 4.9123

>AT272716 WP_150890982.1 NZ_CP118046:c1537340-1537047 [Streptococcus anginosus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLDKTLAVVPLEREQV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F9P6Y3

Antitoxin

Source ID Structure

References