Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2414263..2414786 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag PUW46_RS11905 Protein ID WP_000074043.1
Coordinates 2414263..2414529 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag PUW46_RS11910 Protein ID WP_000587618.1
Coordinates 2414529..2414786 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS11885 (PUW46_11885) 2409569..2410756 - 1188 WP_000026187.1 MFS transporter -
PUW46_RS11890 (PUW46_11890) 2411152..2411928 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
PUW46_RS11895 (PUW46_11895) 2411921..2412583 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
PUW46_RS11900 (PUW46_11900) 2412831..2413907 - 1077 WP_001076665.1 M42 family metallopeptidase -
PUW46_RS11905 (PUW46_11905) 2414263..2414529 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
PUW46_RS11910 (PUW46_11910) 2414529..2414786 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PUW46_RS11915 (PUW46_11915) 2415146..2415601 + 456 WP_000732082.1 DUF1307 domain-containing protein -
PUW46_RS11920 (PUW46_11920) 2415769..2417346 - 1578 WP_000143508.1 FMN-binding glutamate synthase family protein -
PUW46_RS11925 (PUW46_11925) 2417541..2418290 + 750 WP_000072441.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T272714 WP_000074043.1 NZ_CP118044:c2414529-2414263 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT272714 WP_000587618.1 NZ_CP118044:c2414786-2414529 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References