Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2383082..2383266 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag PUW46_RS11765 Protein ID WP_000482650.1
Coordinates 2383159..2383266 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2383082..2383142 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS11750 (PUW46_11750) 2378592..2378759 - 168 WP_001792506.1 hypothetical protein -
PUW46_RS11755 (PUW46_11755) 2378990..2380723 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
PUW46_RS11760 (PUW46_11760) 2380748..2382511 - 1764 WP_001064820.1 ABC transporter ATP-binding protein -
- 2383082..2383142 + 61 - - Antitoxin
PUW46_RS11765 (PUW46_11765) 2383159..2383266 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
PUW46_RS11770 (PUW46_11770) 2383400..2383786 - 387 WP_000779358.1 flippase GtxA -
PUW46_RS11775 (PUW46_11775) 2384044..2385186 + 1143 WP_001176863.1 glycerate kinase -
PUW46_RS11780 (PUW46_11780) 2385246..2385905 + 660 WP_000831298.1 membrane protein -
PUW46_RS11785 (PUW46_11785) 2386087..2387298 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
PUW46_RS11790 (PUW46_11790) 2387421..2387894 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 2366392..2383786 17394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T272713 WP_000482650.1 NZ_CP118044:c2383266-2383159 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT272713 NZ_CP118044:2383082-2383142 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References