Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2356189..2356706 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PUW46_RS11625 Protein ID WP_000113262.1
Coordinates 2356189..2356455 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PUW46_RS11630 Protein ID WP_000584499.1
Coordinates 2356455..2356706 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS11595 (PUW46_11595) 2351612..2352148 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PUW46_RS11600 (PUW46_11600) 2352382..2353206 - 825 WP_000572040.1 formate/nitrite transporter family protein -
PUW46_RS11605 (PUW46_11605) 2353423..2353605 - 183 WP_000079142.1 hypothetical protein -
PUW46_RS11610 (PUW46_11610) 2353692..2354159 - 468 WP_000153344.1 SRPBCC domain-containing protein -
PUW46_RS11615 (PUW46_11615) 2354345..2355895 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PUW46_RS11620 (PUW46_11620) 2356083..2356154 - 72 WP_223200558.1 hypothetical protein -
PUW46_RS11625 (PUW46_11625) 2356189..2356455 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PUW46_RS11630 (PUW46_11630) 2356455..2356706 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PUW46_RS11635 (PUW46_11635) 2356871..2356951 - 81 WP_223197974.1 hypothetical protein -
PUW46_RS11640 (PUW46_11640) 2356979..2357578 - 600 WP_000162803.1 DsbA family protein -
PUW46_RS11645 (PUW46_11645) 2357597..2357959 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PUW46_RS11650 (PUW46_11650) 2358214..2359464 + 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
PUW46_RS11655 (PUW46_11655) 2359561..2360292 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PUW46_RS11660 (PUW46_11660) 2360289..2361008 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T272712 WP_000113262.1 NZ_CP118044:c2356455-2356189 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT272712 WP_000584499.1 NZ_CP118044:c2356706-2356455 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References