272678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2512158..2512660 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag PT280_RS12240 Protein ID WP_000767829.1
Coordinates 2512406..2512660 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PT280_RS12235 Protein ID WP_001259255.1
Coordinates 2512158..2512409 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS12210 (2507336) 2507336..2508403 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PT280_RS12215 (2508403) 2508403..2509473 - 1071 WP_000108957.1 histidinol-phosphate transaminase -
PT280_RS12220 (2509470) 2509470..2510774 - 1305 WP_001349967.1 histidinol dehydrogenase -
PT280_RS12225 (2510780) 2510780..2511679 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PT280_RS12230 (2511825) 2511825..2511875 - 51 WP_001364200.1 his operon leader peptide -
PT280_RS12235 (2512158) 2512158..2512409 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PT280_RS12240 (2512406) 2512406..2512660 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PT280_RS12245 (2512743) 2512743..2513567 + 825 WP_000754749.1 SDR family oxidoreductase -
PT280_RS12250 (2513613) 2513613..2514542 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
PT280_RS12255 (2514757) 2514757..2514819 + 63 WP_010723108.1 membrane protein YoeI -
PT280_RS12260 (2514809) 2514809..2516167 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PT280_RS12265 (2516346) 2516346..2517404 + 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
PT280_RS12270 (2517418) 2517418..2517645 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T272678 WP_000767829.1 NZ_CP118014:2512406-2512660 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT272678 WP_001259255.1 NZ_CP118014:2512158-2512409 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References