272674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1201992..1202791 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag PT280_RS05880 Protein ID WP_000347267.1
Coordinates 1201992..1202456 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PT280_RS05885 Protein ID WP_001307405.1
Coordinates 1202456..1202791 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS05850 (1196993) 1196993..1197427 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PT280_RS05855 (1197445) 1197445..1198323 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
PT280_RS05860 (1198313) 1198313..1199092 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PT280_RS05865 (1199103) 1199103..1199576 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PT280_RS05870 (1199599) 1199599..1200879 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
PT280_RS05875 (1201128) 1201128..1201937 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PT280_RS05880 (1201992) 1201992..1202456 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PT280_RS05885 (1202456) 1202456..1202791 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PT280_RS05890 (1202940) 1202940..1204511 - 1572 WP_001273741.1 galactarate dehydratase -
PT280_RS05895 (1204886) 1204886..1206220 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PT280_RS05900 (1206236) 1206236..1207006 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1201992..1213666 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T272674 WP_000347267.1 NZ_CP118014:c1202456-1201992 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT272674 WP_001307405.1 NZ_CP118014:c1202791-1202456 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References