272670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 386067..386669 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PT280_RS01895 Protein ID WP_000897305.1
Coordinates 386358..386669 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PT280_RS01890 Protein ID WP_000356397.1
Coordinates 386067..386357 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS01865 (381993) 381993..382895 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PT280_RS01870 (382892) 382892..383527 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PT280_RS01875 (383524) 383524..384453 + 930 WP_000027702.1 formate dehydrogenase accessory protein FdhE -
PT280_RS01880 (384783) 384783..385025 - 243 WP_001086388.1 protein YiiF -
PT280_RS01885 (385244) 385244..385462 - 219 WP_001295676.1 CopG family transcriptional regulator -
PT280_RS01890 (386067) 386067..386357 - 291 WP_000356397.1 NadS family protein Antitoxin
PT280_RS01895 (386358) 386358..386669 - 312 WP_000897305.1 hypothetical protein Toxin
PT280_RS01900 (386898) 386898..387806 + 909 WP_001162704.1 alpha/beta hydrolase -
PT280_RS01905 (387870) 387870..388811 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PT280_RS01910 (388856) 388856..389293 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PT280_RS01915 (389290) 389290..390162 - 873 WP_000920762.1 virulence factor BrkB family protein -
PT280_RS01920 (390156) 390156..390755 - 600 WP_001315111.1 glucose-1-phosphatase -
PT280_RS01925 (390854) 390854..391639 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T272670 WP_000897305.1 NZ_CP118014:c386669-386358 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT272670 WP_000356397.1 NZ_CP118014:c386357-386067 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References