Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 941253..941928 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUO93_RS05315 Protein ID WP_048246973.1
Coordinates 941629..941928 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag PUO93_RS05310 Protein ID WP_015571639.1
Coordinates 941253..941618 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS05290 937709..938443 + 735 WP_048246966.1 methyltransferase domain-containing protein -
PUO93_RS05295 938437..939039 - 603 WP_045906890.1 short chain dehydrogenase -
PUO93_RS05300 939137..940024 + 888 WP_033487545.1 LysR family transcriptional regulator -
PUO93_RS05305 940045..941226 + 1182 WP_015571640.1 PLP-dependent aminotransferase family protein -
PUO93_RS05310 941253..941618 - 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
PUO93_RS05315 941629..941928 - 300 WP_048246973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUO93_RS05320 942179..943378 - 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
PUO93_RS05325 943359..945551 - 2193 WP_274292343.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11601.25 Da        Isoelectric Point: 9.6774

>T272654 WP_048246973.1 NZ_CP117993:c941928-941629 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPNKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT272654 WP_015571639.1 NZ_CP117993:c941618-941253 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References