Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 106961..107484 Replicon chromosome
Accession NZ_CP117979
Organism Staphylococcus aureus strain B-41012

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag PT798_RS00510 Protein ID WP_137075561.1
Coordinates 106961..107227 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag PT798_RS00515 Protein ID WP_000587618.1
Coordinates 107227..107484 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT798_RS00490 102267..103454 - 1188 WP_000026194.1 MFS transporter -
PT798_RS00495 103850..104626 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
PT798_RS00500 104619..105281 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
PT798_RS00505 105529..106605 - 1077 WP_001076673.1 M42 family metallopeptidase -
PT798_RS00510 106961..107227 - 267 WP_137075561.1 Txe/YoeB family addiction module toxin Toxin
PT798_RS00515 107227..107484 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PT798_RS00520 107843..108298 + 456 WP_000732076.1 DUF1307 domain-containing protein -
PT798_RS00525 108466..110043 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
PT798_RS00530 110238..110987 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
PT798_RS00535 111218..112411 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10671.52 Da        Isoelectric Point: 10.4303

>T272637 WP_137075561.1 NZ_CP117979:c107227-106961 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKKNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT272637 WP_000587618.1 NZ_CP117979:c107484-107227 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References