Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 580496..581098 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PT747_RS02655 Protein ID WP_001159630.1
Coordinates 580496..580807 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PT747_RS02660 Protein ID WP_000362050.1
Coordinates 580808..581098 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS02630 (576464) 576464..577063 + 600 WP_000965695.1 glucose-1-phosphatase -
PT747_RS02635 (577057) 577057..577929 + 873 WP_023235429.1 virulence factor BrkB family protein -
PT747_RS02640 (577926) 577926..578363 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PT747_RS02645 (578408) 578408..579349 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PT747_RS02650 (579363) 579363..580278 - 916 Protein_511 alpha/beta hydrolase -
PT747_RS02655 (580496) 580496..580807 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PT747_RS02660 (580808) 580808..581098 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PT747_RS02665 (581145) 581145..582074 - 930 WP_001541226.1 formate dehydrogenase accessory protein FdhE -
PT747_RS02670 (582071) 582071..582706 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PT747_RS02675 (582703) 582703..583605 - 903 WP_001541228.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T272620 WP_001159630.1 NZ_CP117976:580496-580807 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272620 WP_000362050.1 NZ_CP117976:580808-581098 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References