272615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6576270..6576865 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PT746_RS31080 Protein ID WP_071534808.1
Coordinates 6576270..6576548 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PT746_RS31085 Protein ID WP_004352673.1
Coordinates 6576560..6576865 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS31060 6571696..6572934 + 1239 WP_003113524.1 dipeptidase -
PT746_RS31065 6572996..6573643 + 648 WP_003095021.1 carbonate dehydratase -
PT746_RS31070 6573713..6575941 - 2229 WP_004352671.1 TonB-dependent receptor -
PT746_RS31075 6576089..6576217 + 129 Protein_6136 integrase -
PT746_RS31080 6576270..6576548 + 279 WP_071534808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT746_RS31085 6576560..6576865 + 306 WP_004352673.1 HigA family addiction module antitoxin Antitoxin
PT746_RS31090 6577372..6578259 + 888 WP_124989691.1 sce7726 family protein -
PT746_RS31095 6578220..6579134 + 915 WP_124989690.1 sce7725 family protein -
PT746_RS31100 6579177..6579512 - 336 WP_029528819.1 hypothetical protein -
PT746_RS31105 6579959..6580231 + 273 WP_003115921.1 hypothetical protein -
PT746_RS31110 6580443..6580733 + 291 WP_049295997.1 DUF5447 family protein -
PT746_RS31115 6581271..6581705 + 435 WP_003140508.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 8.5576

>T272615 WP_071534808.1 NZ_CP117974:6576270-6576548 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11238.80 Da        Isoelectric Point: 4.7769

>AT272615 WP_004352673.1 NZ_CP117974:6576560-6576865 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References