Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2747285..2747787 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag PT746_RS12705 Protein ID WP_023081358.1
Coordinates 2747285..2747539 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag PT746_RS12710 Protein ID WP_004350479.1
Coordinates 2747536..2747787 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS12685 2743720..2744583 + 864 WP_004350470.1 integrase domain-containing protein -
PT746_RS12690 2744771..2745121 + 351 WP_023081356.1 hypothetical protein -
PT746_RS12695 2745136..2746656 + 1521 WP_004350477.1 conjugal transfer protein TraG N-terminal domain-containing protein -
PT746_RS12700 2746664..2747059 - 396 WP_023081357.1 DUF3742 family protein -
PT746_RS12705 2747285..2747539 - 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
PT746_RS12710 2747536..2747787 - 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PT746_RS12715 2748010..2749242 - 1233 Protein_2514 tyrosine-type recombinase/integrase -
PT746_RS12725 2749610..2750170 - 561 WP_003090349.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
PT746_RS12730 2750204..2752030 - 1827 WP_003097551.1 excinuclease ABC subunit UvrC -
PT746_RS12735 2752031..2752675 - 645 WP_003090351.1 UvrY/SirA/GacA family response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2738562..2747787 9225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T272612 WP_023081358.1 NZ_CP117974:c2747539-2747285 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT272612 WP_004350479.1 NZ_CP117974:c2747787-2747536 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References