272595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2127793..2128295 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag PT723_RS10090 Protein ID WP_000767829.1
Coordinates 2128041..2128295 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PT723_RS10085 Protein ID WP_001259255.1
Coordinates 2127793..2128044 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS10060 (2122971) 2122971..2124038 - 1068 WP_137044251.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PT723_RS10065 (2124038) 2124038..2125108 - 1071 WP_000108994.1 histidinol-phosphate transaminase -
PT723_RS10070 (2125105) 2125105..2126409 - 1305 WP_024240936.1 histidinol dehydrogenase -
PT723_RS10075 (2126415) 2126415..2127314 - 900 WP_024240937.1 ATP phosphoribosyltransferase -
PT723_RS10080 (2127460) 2127460..2127510 - 51 WP_001364200.1 his operon leader peptide -
PT723_RS10085 (2127793) 2127793..2128044 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PT723_RS10090 (2128041) 2128041..2128295 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PT723_RS10095 (2128378) 2128378..2129202 + 825 WP_000754737.1 SDR family oxidoreductase -
PT723_RS10100 (2129248) 2129248..2130177 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
PT723_RS10105 (2130392) 2130392..2130454 + 63 WP_010723108.1 membrane protein YoeI -
PT723_RS10110 (2130444) 2130444..2131802 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PT723_RS10115 (2131981) 2131981..2133039 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
PT723_RS10120 (2133053) 2133053..2133280 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T272595 WP_000767829.1 NZ_CP117971:2128041-2128295 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT272595 WP_001259255.1 NZ_CP117971:2127793-2128044 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References