Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1061693..1062386 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PT723_RS05130 Protein ID WP_000415584.1
Coordinates 1061693..1061989 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PT723_RS05135 Protein ID WP_000650107.1
Coordinates 1061991..1062386 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS05095 (1056782) 1056782..1057096 - 315 WP_000958598.1 putative quinol monooxygenase -
PT723_RS05100 (1057127) 1057127..1057708 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PT723_RS05105 (1058027) 1058027..1058359 + 333 WP_000917684.1 DUF2645 family protein -
PT723_RS05110 (1058405) 1058405..1059754 - 1350 WP_139935936.1 quorum sensing histidine kinase QseC -
PT723_RS05115 (1059751) 1059751..1060410 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PT723_RS05120 (1060562) 1060562..1060954 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PT723_RS05125 (1061006) 1061006..1061488 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PT723_RS05130 (1061693) 1061693..1061989 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PT723_RS05135 (1061991) 1061991..1062386 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PT723_RS05140 (1062519) 1062519..1064126 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PT723_RS05145 (1064264) 1064264..1066522 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T272592 WP_000415584.1 NZ_CP117971:1061693-1061989 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT272592 WP_000650107.1 NZ_CP117971:1061991-1062386 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References