Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2474863..2475095 Replicon chromosome
Accession NZ_CP117970
Organism Enterococcus faecalis strain B-537

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PT722_RS11935 Protein ID WP_002355568.1
Coordinates 2474979..2475095 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2474863..2475068 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT722_RS11915 (2470350) 2470350..2471438 - 1089 WP_002355572.1 diacylglycerol kinase -
PT722_RS11920 (2471457) 2471457..2472887 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PT722_RS11925 (2472887) 2472887..2474356 - 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PT722_RS11930 (2474356) 2474356..2474661 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- (2474863) 2474863..2475068 + 206 NuclAT_1 - Antitoxin
PT722_RS11935 (2474979) 2474979..2475095 - 117 WP_002355568.1 putative holin-like toxin Toxin
PT722_RS11940 (2475243) 2475243..2477273 - 2031 WP_002364804.1 NAD-dependent DNA ligase LigA -
PT722_RS11945 (2477399) 2477399..2479657 - 2259 WP_002364805.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T272585 WP_002355568.1 NZ_CP117970:c2475095-2474979 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT272585 NZ_CP117970:2474863-2475068 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References