Detailed information of TA system TA272583

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 236035..236371
• Replicon: chromosome
• Accession: NZ_CP117970
• Organism: Enterococcus faecalis strain B-537

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A125WAU0
• Locus tag: PT722_RS01070
• Protein ID: WP_002391551.1
• Coordinates: 236035..236178 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	236322..236371 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT722_RS01055 (231751)	231751..232383	-	633	WP_002358972.1	RloB family protein	-
PT722_RS01060 (232392)	232392..233687	-	1296	WP_002371641.1	ATP-binding protein	-
PT722_RS01065 (234149)	234149..235765	+	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
PT722_RS01070 (236035)	236035..236178	+	144	WP_002391551.1	putative holin-like toxin	Toxin
- (236322)	236322..236371	+	50	NuclAT_7	-	Antitoxin
- (236110)	236110..236372	-	263	NuclAT_6	-	-
PT722_RS01075 (236373)	236373..241064	-	4692	WP_002399468.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5175.17 Da
• Isoelectric Point: 8.6389

>T272583 WP_002391551.1 NZ_CP117970:236035-236178 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 50 bp

>AT272583 NZ_CP117970:236322-236371 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A125WAU0

Antitoxin