Detailed information of TA system TA272576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 85352..85836
• Replicon: chromosome
• Accession: NZ_CP117970
• Organism: Enterococcus faecalis strain B-537

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PT722_RS00385
• Protein ID: WP_075551663.1
• Coordinates: 85352..85453 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	85627..85836 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT722_RS00360 (80877)	80877..81830	-	954	WP_002365350.1	siderophore ABC transporter substrate-binding protein	-
PT722_RS00365 (81869)	81869..82624	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PT722_RS00370 (82621)	82621..83586	-	966	WP_002365351.1	iron chelate uptake ABC transporter family permease subunit	-
PT722_RS00375 (83583)	83583..84530	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PT722_RS00380 (84715)	84715..85167	+	453	WP_002354958.1	YueI family protein	-
- (85193)	85193..85403	+	211	NuclAT_4	-	-
- (85230)	85230..85407	+	178	NuclAT_3	-	-
PT722_RS00385 (85352)	85352..85453	-	102	WP_075551663.1	putative holin-like toxin	Toxin
- (85627)	85627..85836	+	210	NuclAT_5	-	Antitoxin
- (85661)	85661..85840	+	180	NuclAT_2	-	-
PT722_RS00390 (85785)	85785..85886	-	102	WP_075551663.1	putative holin-like toxin	-
PT722_RS00395 (86075)	86075..88345	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PT722_RS00400 (88516)	88516..89016	+	501	WP_002365352.1	cysteine hydrolase family protein	-
PT722_RS00405 (89415)	89415..90311	+	897	WP_002365354.1	YitT family protein	-
PT722_RS00410 (90362)	90362..90760	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T272576 WP_075551663.1 NZ_CP117970:c85453-85352 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT272576 NZ_CP117970:85627-85836 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin