272558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4067857..4068359 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag PT299_RS20810 Protein ID WP_000767829.1
Coordinates 4068105..4068359 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PT299_RS20805 Protein ID WP_001259255.1
Coordinates 4067857..4068108 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS20780 (4063035) 4063035..4064102 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PT299_RS20785 (4064102) 4064102..4065172 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
PT299_RS20790 (4065169) 4065169..4066473 - 1305 WP_000009594.1 histidinol dehydrogenase -
PT299_RS20795 (4066479) 4066479..4067378 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PT299_RS20800 (4067524) 4067524..4067574 - 51 WP_001364200.1 his operon leader peptide -
PT299_RS20805 (4067857) 4067857..4068108 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PT299_RS20810 (4068105) 4068105..4068359 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PT299_RS20815 (4068442) 4068442..4069266 + 825 WP_000754737.1 SDR family oxidoreductase -
PT299_RS20820 (4069312) 4069312..4070241 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
PT299_RS20825 (4070456) 4070456..4070518 + 63 WP_010723108.1 membrane protein YoeI -
PT299_RS20830 (4070508) 4070508..4071866 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PT299_RS20835 (4072045) 4072045..4073103 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
PT299_RS20840 (4073117) 4073117..4073344 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T272558 WP_000767829.1 NZ_CP117962:4068105-4068359 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT272558 WP_001259255.1 NZ_CP117962:4067857-4068108 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References