Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2989672..2990365 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PT299_RS15730 Protein ID WP_000415584.1
Coordinates 2989672..2989968 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PT299_RS15735 Protein ID WP_000650107.1
Coordinates 2989970..2990365 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS15695 (2984760) 2984760..2985074 - 315 WP_000958598.1 putative quinol monooxygenase -
PT299_RS15700 (2985105) 2985105..2985686 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PT299_RS15705 (2986005) 2986005..2986337 + 333 WP_000917684.1 DUF2645 family protein -
PT299_RS15710 (2986383) 2986383..2987732 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PT299_RS15715 (2987729) 2987729..2988388 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
PT299_RS15720 (2988540) 2988540..2988932 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PT299_RS15725 (2988985) 2988985..2989467 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PT299_RS15730 (2989672) 2989672..2989968 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PT299_RS15735 (2989970) 2989970..2990365 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PT299_RS15740 (2990498) 2990498..2992105 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PT299_RS15745 (2992243) 2992243..2994501 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T272553 WP_000415584.1 NZ_CP117962:2989672-2989968 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT272553 WP_000650107.1 NZ_CP117962:2989970-2990365 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References