Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 1574226..1574638 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag PT299_RS08900 Protein ID WP_000132601.1
Coordinates 1574297..1574638 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 1574226..1574302 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS08890 (1571089) 1571089..1572678 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
PT299_RS08895 (1572675) 1572675..1574069 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (1574226) 1574226..1574302 - 77 NuclAT_13 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_13 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_13 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_13 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_14 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_14 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_14 - Antitoxin
- (1574226) 1574226..1574302 - 77 NuclAT_14 - Antitoxin
PT299_RS08900 (1574297) 1574297..1574638 + 342 WP_000132601.1 endoribonuclease SymE Toxin
PT299_RS08905 (1574800) 1574800..1576179 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
PT299_RS08910 (1576179) 1576179..1577225 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T272546 WP_000132601.1 NZ_CP117962:1574297-1574638 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT272546 NZ_CP117962:c1574302-1574226 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References