Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3391082..3391775 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag PT288_RS16460 Protein ID WP_000415583.1
Coordinates 3391082..3391378 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PT288_RS16465 Protein ID WP_000650107.1
Coordinates 3391380..3391775 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS16425 (3386170) 3386170..3386484 - 315 WP_000958598.1 putative quinol monooxygenase -
PT288_RS16430 (3386515) 3386515..3387096 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PT288_RS16435 (3387415) 3387415..3387747 + 333 WP_000917684.1 DUF2645 family protein -
PT288_RS16440 (3387793) 3387793..3389142 - 1350 WP_000673401.1 quorum sensing histidine kinase QseC -
PT288_RS16445 (3389139) 3389139..3389798 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PT288_RS16450 (3389950) 3389950..3390342 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PT288_RS16455 (3390395) 3390395..3390877 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PT288_RS16460 (3391082) 3391082..3391378 + 297 WP_000415583.1 type II toxin-antitoxin system toxin MqsR Toxin
PT288_RS16465 (3391380) 3391380..3391775 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PT288_RS16470 (3391908) 3391908..3393515 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PT288_RS16475 (3393653) 3393653..3395911 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.99 Da        Isoelectric Point: 8.9070

>T272526 WP_000415583.1 NZ_CP117960:3391082-3391378 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT272526 WP_000650107.1 NZ_CP117960:3391380-3391775 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References