Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3277923..3278722 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PT288_RS15910 Protein ID WP_000347251.1
Coordinates 3277923..3278387 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag PT288_RS15915 Protein ID WP_012304834.1
Coordinates 3278387..3278722 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS15880 (3272924) 3272924..3273358 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PT288_RS15885 (3273376) 3273376..3274254 - 879 WP_012304833.1 PTS N-acetylgalactosamine transporter subunit IID -
PT288_RS15890 (3274244) 3274244..3275023 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PT288_RS15895 (3275034) 3275034..3275507 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PT288_RS15900 (3275530) 3275530..3276810 - 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
PT288_RS15905 (3277059) 3277059..3277868 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PT288_RS15910 (3277923) 3277923..3278387 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PT288_RS15915 (3278387) 3278387..3278722 - 336 WP_012304834.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PT288_RS15920 (3278871) 3278871..3280442 - 1572 WP_001273760.1 galactarate dehydratase -
PT288_RS15925 (3280817) 3280817..3282151 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PT288_RS15930 (3282167) 3282167..3282937 + 771 WP_001058236.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T272524 WP_000347251.1 NZ_CP117960:c3278387-3277923 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.95 Da        Isoelectric Point: 4.6890

>AT272524 WP_012304834.1 NZ_CP117960:c3278722-3278387 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure

References