Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 1990391..1990803 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name symE Uniprot ID B1IS82
Locus tag PT288_RS09815 Protein ID WP_000132625.1
Coordinates 1990462..1990803 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1990391..1990467 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS09800 (1986595) 1986595..1987756 - 1162 Protein_1918 IS3-like element IS3 family transposase -
PT288_RS09805 (1987822) 1987822..1988484 + 663 Protein_1919 N-6 DNA methylase -
PT288_RS09810 (1988484) 1988484..1990241 + 1758 WP_000110077.1 restriction endonuclease subunit S -
- (1990391) 1990391..1990467 - 77 NuclAT_12 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_12 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_12 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_12 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_13 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_13 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_13 - Antitoxin
- (1990391) 1990391..1990467 - 77 NuclAT_13 - Antitoxin
PT288_RS09815 (1990462) 1990462..1990803 + 342 WP_000132625.1 endoribonuclease SymE Toxin
PT288_RS09820 (1990850) 1990850..1992013 - 1164 WP_225402390.1 DUF1524 domain-containing protein -
PT288_RS09825 (1992061) 1992061..1992943 - 883 Protein_1923 DUF262 domain-containing protein -
PT288_RS09830 (1993086) 1993086..1993238 - 153 WP_001496262.1 hypothetical protein -
PT288_RS09835 (1993381) 1993381..1994793 + 1413 WP_000199353.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12270.10 Da        Isoelectric Point: 8.4952

>T272521 WP_000132625.1 NZ_CP117960:1990462-1990803 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVVVKVMEGCIVLTAQPAAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT272521 NZ_CP117960:c1990467-1990391 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1IS82

Antitoxin

Download structure file

References