Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4502958..4503688 Replicon chromosome
Accession NZ_CP117886
Organism Serratia ureilytica strain KML.E1

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag PTZ17_RS21375 Protein ID WP_004937033.1
Coordinates 4502958..4503269 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ17_RS21380 Protein ID WP_033644489.1
Coordinates 4503266..4503688 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ17_RS21345 (PTZ17_21345) 4498273..4498998 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
PTZ17_RS21350 (PTZ17_21350) 4499051..4500484 + 1434 WP_004937039.1 RNA polymerase factor sigma-54 -
PTZ17_RS21355 (PTZ17_21355) 4500508..4500795 + 288 WP_004937038.1 ribosome hibernation promoting factor -
PTZ17_RS21360 (PTZ17_21360) 4500951..4501412 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
PTZ17_RS21365 (PTZ17_21365) 4501540..4502394 + 855 WP_015379177.1 RNase adapter RapZ -
PTZ17_RS21370 (PTZ17_21370) 4502391..4502663 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
PTZ17_RS21375 (PTZ17_21375) 4502958..4503269 + 312 WP_004937033.1 type II toxin-antitoxin system HigB family toxin Toxin
PTZ17_RS21380 (PTZ17_21380) 4503266..4503688 + 423 WP_033644489.1 helix-turn-helix domain-containing protein Antitoxin
PTZ17_RS21385 (PTZ17_21385) 4503693..4505609 - 1917 WP_033644486.1 PRD domain-containing protein -
PTZ17_RS21390 (PTZ17_21390) 4505661..4506875 - 1215 WP_089195223.1 lactonase family protein -
PTZ17_RS21395 (PTZ17_21395) 4506963..4507703 - 741 WP_016930215.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T272469 WP_004937033.1 NZ_CP117886:4502958-4503269 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT272469 WP_033644489.1 NZ_CP117886:4503266-4503688 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GR63

Antitoxin

Source ID Structure

References