Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4502958..4503688 Replicon chromosome
Accession NZ_CP117886
Organism Serratia ureilytica strain KML.E1

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag PTZ17_RS21375 Protein ID WP_004937033.1
Coordinates 4502958..4503269 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ17_RS21380 Protein ID WP_033644489.1
Coordinates 4503266..4503688 (+) Length 141 a.a.

Genomic Context

PTZ17_RS21345PTZ17_RS21350PTZ17_RS21355PTZ17_RS21360PTZ17_RS21365PTZ17_RS21370PTZ17_RS21375PTZ17_RS21380PTZ17_RS21385PTZ17_RS21390PTZ17_RS21395
Location: 4498273..4498998 (726 bp)
Type: Others
Protein ID: WP_004937040.1
Location: 4499051..4500484 (1434 bp)
Type: Others
Protein ID: WP_004937039.1
Location: 4500508..4500795 (288 bp)
Type: Others
Protein ID: WP_004937038.1
Location: 4500951..4501412 (462 bp)
Type: Others
Protein ID: WP_016930212.1
Location: 4501540..4502394 (855 bp)
Type: Others
Protein ID: WP_015379177.1
Location: 4502391..4502663 (273 bp)
Type: Others
Protein ID: WP_004937034.1
Location: 4502958..4503269 (312 bp)
Type: Toxin
Protein ID: WP_004937033.1
Location: 4503266..4503688 (423 bp)
Type: Antitoxin
Protein ID: WP_033644489.1
Location: 4503693..4505609 (1917 bp)
Type: Others
Protein ID: WP_033644486.1
Location: 4505661..4506875 (1215 bp)
Type: Others
Protein ID: WP_089195223.1
Location: 4506963..4507703 (741 bp)
Type: Others
Protein ID: WP_016930215.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PTZ17_RS21345 (PTZ17_21345)4498273..4498998+726WP_004937040.1LPS export ABC transporter ATP-binding protein-
PTZ17_RS21350 (PTZ17_21350)4499051..4500484+1434WP_004937039.1RNA polymerase factor sigma-54-
PTZ17_RS21355 (PTZ17_21355)4500508..4500795+288WP_004937038.1ribosome hibernation promoting factor-
PTZ17_RS21360 (PTZ17_21360)4500951..4501412+462WP_016930212.1PTS IIA-like nitrogen regulatory protein PtsN-
PTZ17_RS21365 (PTZ17_21365)4501540..4502394+855WP_015379177.1RNase adapter RapZ-
PTZ17_RS21370 (PTZ17_21370)4502391..4502663+273WP_004937034.1PTS phosphocarrier protein NPr-
PTZ17_RS21375 (PTZ17_21375)4502958..4503269+312WP_004937033.1type II toxin-antitoxin system HigB family toxinToxin
PTZ17_RS21380 (PTZ17_21380)4503266..4503688+423WP_033644489.1helix-turn-helix domain-containing proteinAntitoxin
PTZ17_RS21385 (PTZ17_21385)4503693..4505609-1917WP_033644486.1PRD domain-containing protein-
PTZ17_RS21390 (PTZ17_21390)4505661..4506875-1215WP_089195223.1lactonase family protein-
PTZ17_RS21395 (PTZ17_21395)4506963..4507703-741WP_016930215.1KDGP aldolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T272469 WP_004937033.1 NZ_CP117886:4502958-4503269 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT272469 WP_033644489.1 NZ_CP117886:4503266-4503688 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4GR63

Antitoxin

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Source
ID
Structure
No matching records found

References