Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4117321..4117973 Replicon chromosome
Accession NZ_CP117886
Organism Serratia ureilytica strain KML.E1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTZ17_RS19595 Protein ID WP_274252768.1
Coordinates 4117321..4117665 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ17_RS19600 Protein ID WP_025304078.1
Coordinates 4117671..4117973 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ17_RS19585 (PTZ17_19585) 4113664..4115922 - 2259 WP_274252766.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
PTZ17_RS19590 (PTZ17_19590) 4116143..4117162 + 1020 WP_033644840.1 HTH-type transcriptional regulator GalR -
PTZ17_RS19595 (PTZ17_19595) 4117321..4117665 + 345 WP_274252768.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTZ17_RS19600 (PTZ17_19600) 4117671..4117973 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
PTZ17_RS19605 (PTZ17_19605) 4118001..4119263 - 1263 WP_033644838.1 diaminopimelate decarboxylase -
PTZ17_RS19610 (PTZ17_19610) 4119397..4120320 + 924 WP_042785280.1 LysR family transcriptional regulator -
PTZ17_RS19615 (PTZ17_19615) 4120348..4121256 - 909 WP_033644836.1 LysR family transcriptional regulator -
PTZ17_RS19620 (PTZ17_19620) 4121365..4122249 + 885 WP_069100465.1 MBL fold metallo-hydrolase -
PTZ17_RS19625 (PTZ17_19625) 4122318..4122965 + 648 WP_033644834.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13338.45 Da        Isoelectric Point: 11.2001

>T272467 WP_274252768.1 NZ_CP117886:4117321-4117665 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSEAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMKFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT272467 WP_025304078.1 NZ_CP117886:4117671-4117973 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References