Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 409876..410600 Replicon chromosome
Accession NZ_CP117874
Organism Pectobacterium carotovorum subsp. carotovorum strain ZJ-4-2

Toxin (Protein)


Gene name higB Uniprot ID A0A7V8TLN0
Locus tag PSR30_RS01850 Protein ID WP_039504225.1
Coordinates 409876..410187 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PSR30_RS01855 Protein ID WP_261846063.1
Coordinates 410184..410600 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR30_RS01830 (PSR30_01830) 405825..407360 - 1536 WP_039507301.1 carbohydrate porin -
PSR30_RS01835 (PSR30_01835) 407560..408483 - 924 WP_226509727.1 aminoimidazole riboside kinase -
PSR30_RS01840 (PSR30_01840) 408807..408995 + 189 WP_039470389.1 hypothetical protein -
PSR30_RS01845 (PSR30_01845) 409165..409716 + 552 WP_261846062.1 polymer-forming cytoskeletal protein -
PSR30_RS01850 (PSR30_01850) 409876..410187 + 312 WP_039504225.1 type II toxin-antitoxin system HigB family toxin Toxin
PSR30_RS01855 (PSR30_01855) 410184..410600 + 417 WP_261846063.1 helix-turn-helix domain-containing protein Antitoxin
PSR30_RS01860 (PSR30_01860) 410806..411264 + 459 WP_040031891.1 hypothetical protein -
PSR30_RS01865 (PSR30_01865) 411362..412714 - 1353 WP_226294620.1 pyridoxal-dependent decarboxylase -
PSR30_RS01870 (PSR30_01870) 412766..414022 - 1257 WP_274214717.1 MFS transporter -
PSR30_RS01875 (PSR30_01875) 414176..414622 + 447 WP_274214718.1 helix-turn-helix domain-containing protein -
PSR30_RS01880 (PSR30_01880) 414632..415099 + 468 WP_039507317.1 YhbP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(4-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12406.28 Da        Isoelectric Point: 10.0380

>T272439 WP_039504225.1 NZ_CP117874:409876-410187 [Pectobacterium carotovorum subsp. carotovorum]
MHVISRAPFDTATTQFPNQAAALADLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15432.68 Da        Isoelectric Point: 4.4558

>AT272439 WP_261846063.1 NZ_CP117874:410184-410600 [Pectobacterium carotovorum subsp. carotovorum]
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERIKALPAGI
ALLRVLMDQYQLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8TLN0

Antitoxin

Source ID Structure

References