Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 507429..508031 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag PTZ66_RS02430 Protein ID WP_001159628.1
Coordinates 507429..507740 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ66_RS02435 Protein ID WP_000362050.1
Coordinates 507741..508031 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS02395 (502542) 502542..503141 + 600 WP_000965702.1 glucose-1-phosphatase -
PTZ66_RS02400 (503135) 503135..504007 + 873 WP_000921423.1 virulence factor BrkB family protein -
PTZ66_RS02405 (504004) 504004..504441 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PTZ66_RS02410 (504486) 504486..505427 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PTZ66_RS02415 (505442) 505442..505888 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PTZ66_RS02420 (505885) 505885..506196 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PTZ66_RS02425 (506282) 506282..507211 - 930 WP_017441897.1 alpha/beta hydrolase -
PTZ66_RS02430 (507429) 507429..507740 + 312 WP_001159628.1 hypothetical protein Toxin
PTZ66_RS02435 (507741) 507741..508031 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PTZ66_RS02440 (508078) 508078..509007 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PTZ66_RS02445 (509004) 509004..509639 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PTZ66_RS02450 (509636) 509636..510538 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T272388 WP_001159628.1 NZ_CP117852:507429-507740 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272388 WP_000362050.1 NZ_CP117852:507741-508031 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References