Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1688200..1688802 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag PTZ67_RS08290 Protein ID WP_001159628.1
Coordinates 1688491..1688802 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ67_RS08285 Protein ID WP_000362050.1
Coordinates 1688200..1688490 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS08270 (1685693) 1685693..1686595 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PTZ67_RS08275 (1686592) 1686592..1687227 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PTZ67_RS08280 (1687224) 1687224..1688153 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PTZ67_RS08285 (1688200) 1688200..1688490 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PTZ67_RS08290 (1688491) 1688491..1688802 - 312 WP_001159628.1 hypothetical protein Toxin
PTZ67_RS08295 (1689020) 1689020..1689949 + 930 WP_017441897.1 alpha/beta hydrolase -
PTZ67_RS08300 (1690035) 1690035..1690346 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PTZ67_RS08305 (1690343) 1690343..1690789 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PTZ67_RS08310 (1690804) 1690804..1691745 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PTZ67_RS08315 (1691790) 1691790..1692227 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PTZ67_RS08320 (1692224) 1692224..1693096 - 873 WP_000921423.1 virulence factor BrkB family protein -
PTZ67_RS08325 (1693090) 1693090..1693689 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T272372 WP_001159628.1 NZ_CP117851:c1688802-1688491 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272372 WP_000362050.1 NZ_CP117851:c1688490-1688200 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References