Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3010838..3011565 | Replicon | chromosome |
| Accession | NZ_CP117850 | ||
| Organism | Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A418Z4H3 |
| Locus tag | PTZ65_RS14750 | Protein ID | WP_017441960.1 |
| Coordinates | 3011254..3011565 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | PTZ65_RS14745 | Protein ID | WP_000561389.1 |
| Coordinates | 3010838..3011257 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTZ65_RS14715 (3007658) | 3007658..3008186 | + | 529 | Protein_2860 | transposase | - |
| PTZ65_RS14720 (3008332) | 3008332..3008472 | - | 141 | WP_031615664.1 | hypothetical protein | - |
| PTZ65_RS14725 (3008638) | 3008638..3008907 | - | 270 | WP_077907250.1 | hypothetical protein | - |
| PTZ65_RS14730 (3009278) | 3009278..3009697 | + | 420 | WP_017441959.1 | GNAT family N-acetyltransferase | - |
| PTZ65_RS14735 (3009933) | 3009933..3010091 | - | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| PTZ65_RS14740 (3010088) | 3010088..3010582 | - | 495 | WP_077907251.1 | glycosyltransferase | - |
| PTZ65_RS14745 (3010838) | 3010838..3011257 | - | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PTZ65_RS14750 (3011254) | 3011254..3011565 | - | 312 | WP_017441960.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| PTZ65_RS14755 (3011744) | 3011744..3012043 | + | 300 | WP_017441961.1 | hypothetical protein | - |
| PTZ65_RS14760 (3012342) | 3012342..3013286 | - | 945 | WP_017441962.1 | DUF2971 domain-containing protein | - |
| PTZ65_RS14765 (3013487) | 3013487..3013639 | - | 153 | WP_153257556.1 | hypothetical protein | - |
| PTZ65_RS14770 (3013791) | 3013791..3014267 | - | 477 | WP_017441964.1 | hypothetical protein | - |
| PTZ65_RS14775 (3014595) | 3014595..3014990 | - | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| PTZ65_RS14780 (3015671) | 3015671..3016393 | + | 723 | WP_017441965.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3007848..3008186 | 338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12453.27 Da Isoelectric Point: 10.1599
>T272354 WP_017441960.1 NZ_CP117850:c3011565-3011254 [Salmonella enterica subsp. enterica serovar Mbandaka]
MHVISKEPFDEAARRYPNDSLAIKALYRLVRERDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVRERDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT272354 WP_000561389.1 NZ_CP117850:c3011257-3010838 [Salmonella enterica subsp. enterica serovar Mbandaka]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|