Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1365587..1366125 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag PTZ65_RS06655 Protein ID WP_001526148.1
Coordinates 1365850..1366125 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A3V4SM47
Locus tag PTZ65_RS06650 Protein ID WP_017441598.1
Coordinates 1365587..1365847 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS06635 (1361340) 1361340..1362893 + 1554 WP_017441601.1 TROVE domain-containing protein -
PTZ65_RS06640 (1363241) 1363241..1364455 + 1215 WP_017441600.1 RNA-splicing ligase RtcB -
PTZ65_RS06645 (1364459) 1364459..1365478 + 1020 WP_017441599.1 RNA 3'-terminal phosphate cyclase -
PTZ65_RS06650 (1365587) 1365587..1365847 + 261 WP_017441598.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PTZ65_RS06655 (1365850) 1365850..1366125 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
PTZ65_RS06660 (1366213) 1366213..1368918 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T272347 WP_001526148.1 NZ_CP117850:1365850-1366125 [Salmonella enterica subsp. enterica serovar Mbandaka]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9460.83 Da        Isoelectric Point: 4.4734

>AT272347 WP_017441598.1 NZ_CP117850:1365587-1365847 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGIDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SM47

References