Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 824603..825205 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag PTZ65_RS04105 Protein ID WP_001159628.1
Coordinates 824894..825205 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTZ65_RS04100 Protein ID WP_000362050.1
Coordinates 824603..824893 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS04085 (822096) 822096..822998 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PTZ65_RS04090 (822995) 822995..823630 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PTZ65_RS04095 (823627) 823627..824556 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PTZ65_RS04100 (824603) 824603..824893 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PTZ65_RS04105 (824894) 824894..825205 - 312 WP_001159628.1 hypothetical protein Toxin
PTZ65_RS04110 (825423) 825423..826352 + 930 WP_017441897.1 alpha/beta hydrolase -
PTZ65_RS04115 (826438) 826438..826749 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PTZ65_RS04120 (826746) 826746..827192 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PTZ65_RS04125 (827207) 827207..828148 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PTZ65_RS04130 (828193) 828193..828630 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PTZ65_RS04135 (828627) 828627..829499 - 873 WP_000921423.1 virulence factor BrkB family protein -
PTZ65_RS04140 (829493) 829493..830092 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T272343 WP_001159628.1 NZ_CP117850:c825205-824894 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272343 WP_000362050.1 NZ_CP117850:c824893-824603 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References