Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3592173..3592830 Replicon chromosome
Accession NZ_CP117838
Organism Enterobacter sp. S-33

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUP35_RS16915 Protein ID WP_111965881.1
Coordinates 3592173..3592472 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MZ32
Locus tag PUP35_RS16920 Protein ID WP_063408808.1
Coordinates 3592483..3592830 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP35_RS16905 3588544..3590742 + 2199 WP_274240648.1 type I secretion system permease/ATPase -
PUP35_RS16910 3590753..3591922 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
PUP35_RS16915 3592173..3592472 + 300 WP_111965881.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP35_RS16920 3592483..3592830 + 348 WP_063408808.1 HigA family addiction module antitoxin Antitoxin
PUP35_RS16925 3592851..3593369 - 519 WP_133295004.1 hypothetical protein -
PUP35_RS16930 3593455..3594636 - 1182 WP_274240649.1 PLP-dependent aminotransferase family protein -
PUP35_RS16935 3594657..3595544 - 888 WP_115876110.1 LysR family transcriptional regulator -
PUP35_RS16940 3595642..3596244 + 603 WP_023308908.1 short chain dehydrogenase -
PUP35_RS16945 3596361..3597740 - 1380 WP_274240650.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11654.27 Da        Isoelectric Point: 9.6244

>T272336 WP_111965881.1 NZ_CP117838:3592173-3592472 [Enterobacter sp. S-33]
MISYFRDQWLEDFFLYGRSSNVIPSNLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFCW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13039.98 Da        Isoelectric Point: 7.0134

>AT272336 WP_063408808.1 NZ_CP117838:3592483-3592830 [Enterobacter sp. S-33]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MZ32

References