Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1169383..1170110 Replicon chromosome
Accession NZ_CP117838
Organism Enterobacter sp. S-33

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUP35_RS05430 Protein ID WP_115874429.1
Coordinates 1169799..1170110 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUP35_RS05425 Protein ID WP_115874428.1
Coordinates 1169383..1169802 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP35_RS05390 1165347..1166237 + 891 WP_274242266.1 oxidoreductase -
PUP35_RS05395 1166234..1166335 - 102 Protein_1045 AraC family transcriptional regulator -
PUP35_RS05400 1166502..1166771 + 270 WP_274242267.1 hypothetical protein -
PUP35_RS05405 1166887..1167186 - 300 WP_274242268.1 hypothetical protein -
PUP35_RS05410 1167417..1167920 - 504 WP_274242269.1 DUF2569 domain-containing protein -
PUP35_RS05415 1168202..1168792 - 591 WP_115874426.1 hypothetical protein -
PUP35_RS05420 1168903..1169313 - 411 WP_115874427.1 Imm63 family immunity protein -
PUP35_RS05425 1169383..1169802 - 420 WP_115874428.1 helix-turn-helix domain-containing protein Antitoxin
PUP35_RS05430 1169799..1170110 - 312 WP_115874429.1 type II toxin-antitoxin system HigB family toxin Toxin
PUP35_RS05435 1170436..1171332 - 897 WP_274242270.1 LysR family transcriptional regulator -
PUP35_RS05440 1171462..1172034 + 573 WP_115874431.1 flavin reductase -
PUP35_RS05445 1172218..1172673 - 456 WP_115874432.1 hypothetical protein -
PUP35_RS05450 1172905..1173936 - 1032 WP_115874433.1 C45 family peptidase -
PUP35_RS05455 1173958..1174680 - 723 WP_024906944.1 glutamine ABC transporter ATP-binding protein GlnQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12369.23 Da        Isoelectric Point: 10.2554

>T272330 WP_115874429.1 NZ_CP117838:c1170110-1169799 [Enterobacter sp. S-33]
MHVVSRAPFDTATRHFPNQALALDDLYRVLKKEHYSSPGDMRKRFPTLDRMKYREKWWVIDVGGGHLRVIFFADFERGKI
FIKHISTHAEYDKLTDLYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15553.70 Da        Isoelectric Point: 4.9801

>AT272330 WP_115874428.1 NZ_CP117838:c1169802-1169383 [Enterobacter sp. S-33]
MNYAAAIKAANELTNELPFLGSSPSRQDYEDALAMVEHLIEHEPDSPLVEMLTAKIDKYENESPEFAEFNARVARIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGK

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References